The Seed Extract of Cassia obtusifolia Ameliorates Learning and Memory Impairments Induced by Scopolamine or Transient Cerebral Hypoperfusion in Mice

author Dong Hyun Kim, Byung Hoon Yoon, Yong-Won Kim, Seungjoo Lee, Bum Young Shin, Ji Wook Jung, Hyoung Ja Kim, Yong Sup Lee, Jae Sue Choi, Sun Yeou Kim, Kyung-Tae Lee, Jong Hoon Ryu
his workplace 1Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, #1 Hoeki-dong, Dongdaemoon-Ku, Seoul 130-701, Korea2Department of Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, #1 Hoeki-dong, Dongdaemoon-Ku, Seoul 130-701, Korea3Department of Herbal Medicinal Resource, College of Health and Welfare, Daegu Haany University, Gyeongsan 712-715, Korea4Faculty of Food Science and Biotechnology, Pukyong National University, Busan 608-737, Korea5Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoeki-dong, Dongdaemoon-Ku, Seoul 130-701, Korea6Present address: Department of Life and Nanopharmaceutical Science, Kyung Hee University, #1 Hoeki-dong, Dongdeamoon-ku, Seoul 130-701, Korea
periodicalJournal of Pharmacological Sciences, 2007, Vol.105 (1), pp.82-93
sourceElsevier Journal
DOI10.1254/jphs.FP0061565
key word Cassia obtusifolia; Memory; Scopolamine; Common carotid artery occlusion; Acetylcholinesterase;
Original abstractAbstract(#br)In the present study, we assessed the effect of the ethanolic extract of the seeds of Cassia obtusifolia (COE) on the learning and memory impairments induced by scopolamine or transient bilateral common carotid artery occlusion (2VO). In a study of the cholinergic dysfunction induced by scopolamine, single COE (25, 50, or 100 mg/kg, p.o.) administration significantly attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks ( P and prolonged swimming time in the target quadrant during a probe trial of the Morris water maze task ( P
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