Cassia tora Seed Extract and Its Active Compound Aurantio-obtusin Inhibit Allergic Responses in IgE-Mediated Mast Cells and Anaphylactic Models.

author Kim Myungsuk, Lim Sue Ji, Lee Hee-Ju, Nho Chu Won
his workplace 1Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute , Gangwon, Korea.
periodicalJournal of agricultural and food chemistry, 2015, Vol.63 (41), pp.9037-46
sourcePubMed Journal
DOI10.1021/acs.jafc.5b03836
key word Cassia tora; IgE-mediated allergic diseases; RBL-2H3 mast cells; Aurantio-obtusin;
Original abstractCassia tora seed is widely used due to its various biological properties including anticancer, antidiabetic, and anti-inflammatory effects. However, there has been no report of the effects of C. tora seed extract (CTE) on immunoglobulin E (IgE)-mediated allergic responses. In this research, we demonstrated the effects of CTE and its active compound aurantio-obtusin on IgE-sensitized allergic reactions in mast cells and passive cutaneous anaphylaxis (PCA). CTE and aurantio-obtusin suppressed degranulation, histamine production, and reactive oxygen species generation and inhibited the production and mRNA expression of tumor necrosis factor-α and interleukin-4. CTE and aurantio-obtusin also suppressed the prostaglandin E2 production and expression of cyclooxygenase 2. Furthermore, CTE and aurantio-obtusin suppressed IgE-mediated FcεRI signaling such as phosphorylation of Syk, protein kinase Cμ, phospholipase Cγ, and extracellular signal-regulated kinases. CTE and aurantio-obtusin blocked mast cell-dependent PCA in IgE-mediated mice. These results suggest that CTE and aurantio-obtusin are a beneficial treatment for allergy-related diseases.
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