The effect of cassia seed extract on the regulation of the LKB1-AMPK-GLUT4 signaling pathway in the skeletal muscle of diabetic rats to improve the insulin sensitivity of the skeletal muscle.

author Wang Qiu-Ying, Tong Ai-Hua, Pan Ying-Ying, Zhang Xian-Dang, Ding Wen-Yu, Xiong Wen
his workplace 1Endocrine Department, Heze Traditional Chinese Medicine Hospital, Heze, Shandong China.2Endocrinology Department, Linyi Central Hospital, Linyi, Shandong China.33Renal Rheumatism Immune Intervention Department, The People's Hospital of Zhangqiu District, Jinan, Shandong China.44Endocrine Department, Shandong Institute of Endocrine & Metabolic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 18877, Jingshi Road, Lixia District, Jinan, 250062 China.
periodicalDiabetology & metabolic syndrome, 2019, Vol.11 , pp.108
sourcePubMed Journal
DOI10.1186/s13098-019-0504-0
key word Cassia seed extract; Diabetes; Insulin sensitivity; LKB1–AMPK–GLUT4; Skeletal muscle;
Original abstractBackground(#br)This study aimed to observe the hypoglycemic effect of cassia seed extract in rats with type-2 diabetes mellitus and its effect on reducing insulin resistance in the skeletal muscle.(#br)Methods(#br)50 rats were randomly divided into the normal, model, high-dose, middle-dose, and low-dose groups of cassia seed extract (n = 10 each). A high-fat diet combined with streptozotocin administration was adopted to build type 2 diabetes models. The cassia seed extract groups were fed different concentrations cassia seed extract while the normal and model groups were fed the same volume of normal saline. The weight, FINS, GIR, insulin tolerance, blood glucose and blood lipid level, oxidative stress indices and expressions related to the LKB1-AMPK-GLUT4 pathway were detected and compared between the two groups.(#br)Results(#br)Compared with the normal group, the model group showed lower weight, glucose infusion rate and expressions related to LKB1-AMPK-GLUT4 pathway and higher FINS, insulin tolerance, blood glucose and blood lipid level and oxidative stress indices (all P
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