Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds

author Weicheng Wang, Yi Zhang, Souichi Nakashima, Seikou Nakamura, Tao Wang, Masayuki Yoshikawa, Hisashi Matsuda
his workplace 1Kyoto Pharmaceutical University2Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine3N.T.H Co., Ltd.
periodicalJournal of Natural Medicines, 2019, Vol.73 (3), pp.439-449
sourceSpringer Nature Journal
DOI10.1007/s11418-018-01276-2
key word Cassia auriculate; Anthracenone dimer glycoside; Melanogenesis inhibitor; Mechanism of action;
abstractAbstract(#br)The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhibitory effects were observed in the concentration range of 0.03 to 0.3 μM. Inhibition of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 protein expression was observed, suggesting that the inhibition of these factors is part of the mechanism of action underlying melanogenesis inhibition.
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