Naphthopyrone glucosides from the seeds of Cassia tora with inhibitory activity on advanced glycation end products (AGEs) formation

author Ga Young Lee, Dae Sik Jang, Yun Mi Lee, Jong Min Kim, Jin Sook Kim
his workplace 1Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine
periodicalArchives of Pharmacal Research, 2006, Vol.29 (7), pp.587-590
sourceSpringer Nature Journal
DOI10.1007/BF02969270
key word Cassia tora; Leguminosae; Cassiaside; Rubrofusarin-6-O-β-D-gentiobioside; Toralactone-9-O-β-D-gentiobioside; Advanced glycation end products (AGEs); Diabetic complications;
abstractAbstract(#br)Three naphthopyrone glucosides, cassiaside ( 1 ), rubrofusarin-6-O-β-D-gentiobioside ( 2 ), and toralactone-9-O-β-D-gentiobioside ( 3 ), were isolated from the BuOH-soluble extract of the seeds of Cassia tora as active constituents, using an, in vitro bioassay based on the inhibition of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structures of 1–3 were determined by spectroscopic data interpretation, particularly by extensive 1D and 2D NMR studies. All the isolates ( 1–3 ) were evaluated for the inhibitory activity on AGEs formation in vitro .
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